The impact of white button mushrooms on prostate cancer reveals promising therapeutic potential through their unique immune-modulating properties.

Researchers at City of Hope Comprehensive Cancer Center discovered that white button mushroom extract can enhance cancer immunotherapy by reducing immune-suppressing cells in tumors while boosting cancer-fighting immune cells.

Key findings from the research include:

• White button mushroom extract decreased myeloid-derived suppressor cells (which normally help cancer evade the immune system)
• The extract increased T cells and natural killer cells that fight cancer
• When combined with immunotherapy, the extract enhanced tumor growth inhibition
• Treated mice survived 8 days longer compared to those receiving only immunotherapy

The mushrooms' effectiveness appears linked to their polysaccharides (β-glucan), which are known to stimulate immune responses. The research included both mouse models and human trials, with eight prostate cancer patients showing improved immune responses after three months of treatment.

Importantly, while the Phase II clinical trials show promise, researchers emphasize:

• The study is still ongoing
• Patients should consult healthcare professionals before taking supplements
• Store-bought mushroom supplements are not FDA-approved
• Adding fresh white button mushrooms to diet is safe and potentially beneficial

These findings suggest mushroom-based compounds could become valuable additions to cancer immunotherapy, though further research is needed to identify the specific beneficial compounds and their mechanisms of action.

Professor Frédéric A. Meunier of the Queensland Brain Institute called it a "really impressive study," noting its comprehensive approach from animal models to human trials and its potential for developing new cancer treatment strategies.

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