Paxlovid is an FDA-approved oral antiviral medication that helps prevent severe illness, hospitalization, and death from COVID-19. The treatment consists of two medications (nirmatrelvir and ritonavir) taken twice daily for five days.

Eligibility Requirements:

• Adults and children 12+ who weigh at least 88 pounds
• Positive COVID-19 test
• Mild-to-moderate symptoms for 5 days or less
• High risk for severe illness

How to Obtain Paxlovid: You can get Paxlovid from:

• State-licensed pharmacists
• Healthcare providers

Required Documentation:

• Current medication list (including OTC)
• Recent health records (less than 12 months old)
• Recent laboratory blood work (liver and kidney function tests)

High-Risk Conditions Include:

• Asthma
• Cancer
• COPD
• Diabetes, heart disease, or stroke
• Kidney, lung, or liver disease
• Overweight or obesity
• Age 65 and older
• Pregnancy
• Weak immune system
• Smoking

Taking Paxlovid:

• Take both pills together twice daily
• Can be taken with or without food
• Swallow whole with water
• Complete full 5-day course
• Maintain consistent timing

Important Considerations:

1. Drug Interactions: Paxlovid may interact with:

   • Antipsychotics
   • Blood thinners
   • Heart rhythm medications
   • Erectile dysfunction drugs
   • Seizure medications
   • St. John's wort
   • Statins

2. Paxlovid Rebound:

   • 1-2% of patients may experience symptom return
   • Can occur 2-8 days after treatment
   • CDC still recommends treatment for high-risk patients

The medication is most effective when started within five days of symptom onset. Despite the possibility of rebound symptoms, Paxlovid remains highly effective at preventing severe COVID-19 outcomes in high-risk patients.

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